A comparison of human motoneuron data to simulated data using cat motoneuron models.

The response of repetitively firing human motoneurons to a composite excitatory input was evaluated. It was clearly shown that the response of the motoneurons to the transient input decreased with an increase in the background firing rate of the cell. The current model of repetitively firing human motoneurons could not account for this experimental result. Therefore, a compartmental modelling approach was used to simulate the repetitive firing properties of anaesthetised cat motoneurons under current clamp conditions. The modelled motoneurons were used in simulations similar to the experimental paradigms where the response to a composite excitatory input was evaluated at different background firing rates. The motoneuron models also showed a decrease in response to the excitatory input at faster background firing rates. The results suggest that human motoneurons are more comparable to motoneurons in the anaesthetised cat preparation than formerly thought. The results also demonstrate that the apparent efficacy of a synaptic input may be modulated by changes in background firing rate of the postsynaptic neuron.